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What is obesity?Obesity is a heavy accumulation of fat in the body's fat cells to such a serious degree that it rapidly increases the risk of obesity-associated diseases and mortality. The fat may be equally distributed on the body, on the stomach (apple-s haped) or on the hips and thighs (pear-shaped). What are the serious obesity-related diseases? Most importantly, being overweight and obese may cause several psychological problems like a feeling of inferiority, often caused by discrimination. Besides, many physical problems are related to obesity, like difficulties in breathing, personal hygiene, pain in the knees and back and skin problems. People suffering from obesity more frequently have high blood pressure and diseases related to hardening of the arteries, with blood clots in the heart and the brain. Other related problems include non-insulin dependent diabetes, gallstones, some types of cancer, difficulties in mobility and increased risk of mortality. What causes obesity? Obesity can be hereditary, therefore some people are at increased risk. However, obesity only develops from overeating, irregular meals and lack of daily physical activity. Many people think that when a disease is hereditary, it is unavoidable that you will suffer from the condition but this is not true. It is lifestyle which determines how the genes develop. Besides genes, food and physical activity, it is possible that other so far unknown elements may play a part. When is medical treatment necessary? The main problem is to limit the treatment to persons who
actually need it such as: Some of the health benefits claimed for a new weight loss drug may not be justified, say experts. Rimonabant, launched in the UK last summer, has been shown to aid weight loss by reducing appetite. But a Drug and Therapeutics Bulletin paper suggests claims that it also has an additional positive impact on the body's chemistry have not been proved. However, the manufacturers said the findings had proved consistent across all trials. The National Institute for Health and Clinical Excellence (Nice) is currently appraising the drug for use on the NHS. Manufacturers Sanofi-Aventis claim it has been shown to cut levels of potentially harmful cholesterol, fats and sugars in the blood to a greater extent than would be expected by weight loss alone. In theory, this should help to reduce the risk of developing type 2 diabetes and heart disease. But the DTB paper argued that research had failed to prove that any positive impact on body chemistry was solely down to taking the drug. It was possible, for instance, that it was down to advice given to patients taking the drug to lead a more healthy lifestyle, and take more exercise. The paper also highlighted the fact that in trials rimonabant had no effect on levels of "bad" cholesterol, and little or no effect on blood pressure. It said the drug had not been effectively compared with other, cheaper weight loss drugs, such as Xenical (orlistat) and Reductil (sibutramine), which are both approved for NHS use. (C)BBC
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